Genentech, Inc.FOR PEOPLE WITH IDIOPATHIC PULMONARYIPFI TO BE THE ONLY THING THATTAKES MY BREATH AWAYPF may be in your lungs, but giving up is not in your nature,PF is anunpredictable disease The damage to your lungs is meversibleso don't wait. As soon as you ae dagnosed o your pulinsonologistabout starting treatment Esbriet" (plffenksonejis an FDA approvedprescripton med katon for the treatment of Ask your pulmonologistifEsbriet may be right for you.Watch stories of people living wth PF atEsbrietStories comEsbrietWhat should I avoid while taking EsbrlethSensitivity to sunlight Uphotosentitivitysunlight Estriet can make your skinsensitivetaking Esbrietnprescription medicine used totothe sun and the Rightfrom sunlamps andpeople with ng disease cated dopathictanning beds You could get a severe sunbumStomach problems Esbeet may causepulmonary It is not k own itUve sunscreen SPF 50 and wearEsbrietis safe and childrenclothesthat cover your skin you have tobe insuright Tak to your doctor if you get sunbumpain Tel your doctor right away your stomachor arash Taking Esbret with other medicinesproblems get worse or donot go away YourBefore you take Esbrette your doctor aboutthat can make your skin sensitvedoctor may need dhange your done ofal your medical conditions,inkluding if yourhavelver problem have kidney problemEsorket may cause serious side ettects.indude feeling tied insomnia upperpregnant is not known Esbritwia harmincluding Liver problems Calyour doctor rightrespiratory tract infections sinusta heldache.your unborn baby are breastfeedingaway you have unexplained symptoms suchdecreased highland deceasedplan to breastfeedas yoowing your son orthe whoe part ofofappetite These are not the possiblepasses into your breast mikl You and yourside effects of Esbriet.doctor shoud deoder youside of yourCal your doctor for medical advice aboutorbeanteed Tra your doctor about thestomach area(abdomemside effects You may report side ettects tomedicines you take including prescriptonmore easily than normal, feeling tied Yourthe FDA at 1800 FDA 1088 or wwwtdagoviandover the counter medicines, vtamins andis working during your beatment with isbretPlease see Brief Summary of Presolbing information including Patientinformation, for additional mportant Safety Information below.Visit EPatent InformationWhat should avoid whale taking ESERIETAvoid suright ESBRET car your in the sun and thecapsules and fim-coated tabletsyou have to bein suight Takto your docto f you get sunburnorarash.Avoid ES8RET wth medonesthat can make our skinprescripton med cre used 10 people wthalungsensitive tothe san from sunlamps and tamngbeds.disease caled dopahit pulmonary fibrosis PFIAvoid smoking Smokingmay affect how we ESBRETworksarethe possible side effects of ESERIET?Before You take ESBREL tell your doktor about alof your medicalESBRIET may cause serious side effects,intludingconditions including if you:hive liver problem have kidney problemasmoker pegnantor panto become pegnantES8RET wil hem unborn baby ae breistseedingo plan tobreastfeed is not known it ESBRIET passes vouboist Youvou stomach labdomen bleeding or brusing more than noma,and your doctor should decide f you wa take ESBRETell your doctoror feeling tinedYour doctor ail blood tettstoched how vouriver is working daring ourvitamins, and hertalsupoiementsand rana Ser whatHow should I take ESBREThYou doctor charge your dosage of EET as needed.stomach problemsmay cause stomach problems such asTake ESBRIET with food time each day This may hebnausea heartbum and your doctor ng awaw your stomach protems get worse ordosupplied as either a white to ow.whittfeeling tied insomnia.take as foaown:weight and deoteasedor oss of appette These ae not althe possible sideYou may nipon etteots to FDA atdaysKorpina tighty dosed containerEsteriet 267 mg Dosing ScheduleKeep ESBRIET and all medicinesoutoffreach ofwhcht was not presobed. Do not give ES8RETto other people, eventhey have the same symptoms that you have may ham them Youpharmacist or doctor for informaton aboutES8RETthat isWhat are the ingredients in ESBRET tapsuleshhave been prescribed brown mg ES8RETinactive ingredientstimes eachEsbriet 801 mg Dosing ScheduleCapsule Brown Printingink shelac ionoxide blad, aon oxide Med ionaethe ingredients in ESBRET fim coated tabletwpowdone, oroscammelose sodum, magresiunnstelrate polyvinyl acoholyou miss days more ofcal nightESBRE further netructora about you medone.ttanum doode macrogoluke2dows the same sme to make up for your missed dose.0201 Genentech,take more than 3 doses eachRevised January 2012This ntomrution has been approvedvoutiketoo much ESBRET cal your doctor or go netrestbythe US Food and Drug Administrationhospita emergency Roomrigit away.Yourdoctor thould do ortan blood test belore you start takingESBRET

Date: June 17, 2017

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Genentech, Inc.FOR PEOPLE WITH IDIOPATHIC PULMONARY IPF I TO BE THE ONLY THING THAT TAKES MY BREATH AWAY PF may be in your lungs, but giving up is not in your nature, PF is an unpredictable disease The damage to your lungs is meversible so don't wait. As soon as you ae dagnosed o your pulinsonologist about starting treatment Esbriet" (plffenksonej is an FDA approved prescripton med katon for the treatment of Ask your pulmonologist ifEsbriet may be right for you. Watch stories of people living wth PF at EsbrietStories com Esbriet What should I avoid while taking Esbrleth Sensitivity to sunlight Uphotosentitivity sunlight Estriet can make your skinsensitive taking Esbrietn prescription medicine used to tothe sun and the Rightfrom sunlamps and people with ng disease cated dopathic tanning beds You could get a severe sunbum Stomach problems Esbeet may cause pulmonary It is not k own it Uve sunscreen SPF 50 and wear Esbrietis safe and children clothesthat cover your skin you have tobe in suright Tak to your doctor if you get sunbum pain Tel your doctor right away your stomach or arash Taking Esbret with other medicines problems get worse or donot go away Your Before you take Esbrette your doctor about that can make your skin sensitve doctor may need dhange your done of al your medical conditions,inkluding if your havelver problem have kidney problem Esorket may cause serious side ettects. indude feeling tied insomnia upper pregnant is not known Esbritwia harm including Liver problems Calyour doctor right respiratory tract infections sinusta heldache. your unborn baby are breastfeeding away you have unexplained symptoms such decreased highland deceased plan to breastfeed as yoowing your son orthe whoe part of of appetite These are not the possible passes into your breast mikl You and your side effects of Esbriet. doctor shoud deoder you side of your Cal your doctor for medical advice about orbeanteed Tra your doctor about the stomach area(abdomem side effects You may report side ettects to medicines you take including prescripton more easily than normal, feeling tied Your the FDA at 1800 FDA 1088 or wwwtdagovi andover the counter medicines, vtamins and is working during your beatment with isbret Please see Brief Summary of Presolbing information including Patientinformation, for additional mportant Safety Information below. Visit E Patent Information What should avoid whale taking ESERIET Avoid suright ESBRET car your in the sun and the capsules and fim-coated tablets you have to bein suight Takto your docto f you get sunburnorarash. Avoid ES8RET wth medonesthat can make our skin prescripton med cre used 10 people wthalung sensitive tothe san from sunlamps and tamngbeds. disease caled dopahit pulmonary fibrosis PFI Avoid smoking Smoking may affect how we ESBRETworks arethe possible side effects of ESERIET? Before You take ESBREL tell your doktor about alof your medical ESBRIET may cause serious side effects,intluding conditions including if you: hive liver problem have kidney problema smoker pegnantor panto become pegnant ES8RET wil hem unborn baby ae breistseedingo plan to breastfeed is not known it ESBRIET passes vouboist You vou stomach labdomen bleeding or brusing more than noma, and your doctor should decide f you wa take ESBRE Tell your doctor or feeling tined Your doctor ail blood tettstoched how vouriver is working daring our vitamins, and hertalsupoiements and rana Ser what How should I take ESBRETh You doctor charge your dosage of E ET as needed. stomach problems may cause stomach problems such as Take ESBRIET with food time each day This may heb nausea heartbum and your doctor ng awaw your stomach protems get worse ordo supplied as either a white to ow.whitt feeling tied insomnia. take as foaown: weight and deoteased or oss of appette These ae not althe possible side You may nipon etteots to FDA at days Korpina tighty dosed container Esteriet 267 mg Dosing Schedule Keep ESBRIET and all medicinesoutoffreach of whcht was not presobed. Do not give ES8RETto other people, even they have the same symptoms that you have may ham them You pharmacist or doctor for informaton aboutES8RETthat is What are the ingredients in ESBRET tapsulesh have been prescribed brown mg ES8RET inactive ingredients times each Esbriet 801 mg Dosing Schedule Capsule Brown Printingink shelac ionoxide blad, aon oxide Med ion aethe ingredients in ESBRET fim coated tabletw powdone, oroscammelose sodum, magresiunnstelrate polyvinyl acohol you miss days more of cal night ESBRE further netructora about you medone. ttanum doode macrogol uke2dows the same sme to make up for your missed dose. 0201 Genentech, take more than 3 doses each Revised January 2012 This ntomrution has been approved voutiketoo much ESBRET cal your doctor or go netrest bythe US Food and Drug Administration hospita emergency Roomrigit away. Yourdoctor thould do ortan blood test belore you start takingESBRET